Wonpil Im
Department of Bioengineering
Lehigh University

Toward Computational Glycobiology

Tuesday, October 10, 4:00 PM
Packard Lab 416

Abstract:   In this talk, I would like to share our ongoing efforts toward computational (structural) glycobiology in terms of (1) glycan structure and dynamics in glycoproteins, (2) roles of glycans as ligands in protein-glycan and protein-protein interactions, (3) glycolipid structure and dynamics, and (4) bacterial outer membranes containing lipopolysaccharides and their interactions with membrane proteins. We have developed various tools available at GlycanStructure.ORG (http://www.glycanstructure.org): Glycan Reader for automatic detection and annotation of carbohydrates and glycosidic linkages in PDB files, Glycan Fragment DB for carbohydrate fragment structures in the PDB and torsion angle distributions of specific glycosidic linkages of searched structures, Glycan Modeler for modeling glycan structures from its sequence, and GS-align for glycan structure alignment and similarity measurement. A PDB survey study of N-glycan structures and protein-glycan interactions in the PDB is also presented for modeling glycan structures and protein-glycan interactions. In addition, I will also briefly talk about our CHARMM-GUI (http://www.charmm-gui.org) project.

Bio:  Wonpil Im received in bachelor’s and master’s degrees from Hanyang University in Seoul. He then earned his Ph.D. in Biochemistry from Cornell University. He did his post-doctoral research at the Scripps Research Institute in La Jolla, California. In 2005, he was hired as an assistant professor in the Center for Computational Biology and Department of Molecular Biosciences at the University of Kansas, Lawrence. In 2011, he was promoted to associate professor and then professor in 2015. In 2016, he joined the Faculty in Departments of Biological Sciences and Bioengineering at Lehigh University, and he has been named the Presidential Endowed Chair in Health - Science and Engineering. Wonpil was recently awarded the Friedrich Wilhelm Bessel Research Award from the Humboldt Foundation and was named a KIAS Scholar from the Korea Institute for Advanced Study. Prior to Lehigh, he was awarded the Alfred P. Sloan Research Fellowship (2007), ACS HP Outstanding Junior Faculty Award (2011), J. Michael Young Undergrad Advisor Award (2011), Meredith Docking Scholar (2013), and University Scholarly Achievement Award (2015).

Research in his lab is focused on the applications of theoretical/computational methods to chemical and physical problems in biology and material sciences. In particular, he is interested in modeling and simulations of biological membranes and associated proteins, glycoconjugates, and protein-ligand (drug) interactions. In addition, his lab has been developing CHARMM-GUI for the biomolecular modeling and simulation community.

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